The sustained release matrix tablets of cefpodoxime proxetil were prepared by direct compression techniques. The effect of hydrophilic matrices on the behavior of cefpodoxime proxetil using different polymers and their combinations. The prepared tablets were evaluated for various physico-chemical parameters. In-vitro release profile was check for 24 hrs to evaluate the SR matrix tablet of cefpodoxime proxetil. The drug release from the optimized formulation was found to follow zero order kinetics. Thus the phenomenon of drug release showed that the release of optimized formulation is controlled by diffusion. Administration of cefpodoxime proxetil in a sustained release dosage would be more desirable for bacterial infections effects by maintaining the plasma concentrations of the drug well above the therapeutic concentration. From in-vitro dissolution profile, batch F3 was prepared with blend of compritol® 888 ATO and hydroxypropyl methylcellulose (K15M) combination where drug release was about 98.11%.
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